Welcome to the Emenemlab web site.
Our goal in life is experimental molecular dermatology. We focus on the molecular genetics and biology of rare genetic skin disorders, but we also study the impact of epigenetic changes on common diseases, including the most frequent human malignancy: basal cell carcinoma.
We apply the tools and knowledge obtained from the rare to the study of the common. Our mission is to understand skin disease at its most basic level so that we can offer our patients rational and effective treatments for their conditions.
Result of the month
An update was long overdue! So here’s the most recent result that I think is of interest.
Br J Dermatol. 2013 Dec 20. doi: 10.1111/bjd.12799. [Epub ahead of print]
Increased epidermal expression and absence of mutations in CARD14 in a series of sporadic PRP patients.
Eytan O, Qiaoli L, Nousbeck J, van Steensel MA, Burger B, Hohl D, Taieb A, Prey S, Bachmann D, Avitan-Hersh E, Jin Chung H, Shemer A, Trau H, Bergman R,Fuchs-Telem D, Warshauer E, Israeli S, Itin PH, Sarig O, Uitto J, Sprecher E.
Here, Eli Sprecher’s group, with some input by us, shows that sporadic pityriasis rubra pilaris (PRP) is characterised by increased CARD14 expression, meaning that its pathogenesis is basically identical to that of inherited PRP, which is caused by activating CARD14 mutations.
Check out the News page for abstracts of our recent work.